Genetics of essential tremor

Murni Tio, Eng-King Tan

Genes play a major role in Essential Tremor 

Highlights 

  • Essential tremor is one of the most common adult-onset movement disorders.
  • Identifying underlying genes in both monogenic and complex forms of ET has been a challenging task.
  • Recent discoveries linking LINGO1, FUS and TENM4 to essential tremor have been met with cautious optimism.
  • Future genetic studies should include adequate sample size, supported by both functional in vitro and in vivo studies.

 

Essential tremor is one of the most common adult-onset movement disorders. While it is recognised that genes play a major role in ET with ≥50% of the affected individuals having a positive family history, identifying underlying genes in both monogenic and complex forms of ET has been a challenging task. Recent discoveries linking LINGO1, FUS and TENM4 to essential tremor have been met with cautious optimism since reproducibility and pathogenicity have been contentious in previously implicated genes. 

 

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