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Knowledge gaps and research recommendations for essential tremor

Franziska Hopfner, Dietrich Haubenberger, Wendy R. Galpern, Katrina Gwinn, Ashlee Van't Veer, Samantha White, Kailash Bhatia, Charles H. Adler, David Eidelberg, William Ondo, Glenn T. Stebbins, Caroline M. Tanner, Rick C. Helmich, Fred A. Lenz, Roy V. Sillitoe, David Vaillancourt, Jerrold L. Vitek, Elan D. Louis, Holly A. Shill, Matthew P. Frosch, Tatiana Foroud, Gregor Kuhlenbäumer, Andrew Singleton, Claudia M. Testa, Mark Hallett, Rodger Elble, Günther Deuschl


Essential tremor (ET) is a common cause of significant disability, but its etiologies and pathogenesis are poorly understood. Research has been hampered by the variable definition of ET and by non-standardized research approaches. The National Institute of Neurological Disorders and Stroke (USA) invited experts in ET and related fields to discuss current knowledge, controversies, and gaps in our understanding of ET and to develop recommendations for future research. Discussion focused on phenomenology and phenotypes, therapies and clinical trials, pathophysiology, pathology, and genetics.


  • More collaborative and coordinated research across all disciplines is needed for future research in ET.
  • Standardized data collection using common data elements are required.
  • Very large cohorts of patients should be studied prospectively on a multinational level.
  • Characterization of the natural history of the ET syndromes is needed.
  • A neuropathology consortium should be formed and bio-samples should be collected.


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