Research News

Emerging strategies in the management of essential tremor

30 Nov 2016

Currently available therapies for essential tremor (ET) provide sufficient control only for less than a half of patients and many unmet needs exist. Here the authors review the most promising new approaches to treating ET, including allosteric modulation of GABA receptors and modifications of the LINGO-1 pathway. 

Sage Journals

A step toward essential tremor gene discovery: identification of extreme phenotype and screening of HTRA2 and ANO3

23 Nov 2016

This study aimed at exploring ET patients to identify distinct subgroups and facilitate the identification of ET genes. The data support that distinct ET phenotypic subgroups may be encountered and HTRA2 and ANO3 mutations are not common causes of ET.

Bio Med Central Neurology

Approach to a tremor patient

21 Nov 2016

Tremors are commonly encountered in clinical practice and are the most common movement disorders seen. They have varying etiology; hence, classifying them appropriately helps in identifying the underlying cause. Essential tremor (ET) and enhanced physiological tremor are the most common causes of action tremor. Isolated head tremor is more likely to be dystonic rather than ET. Isolated voice tremor could be considered to be a spectrum of ET. Psychogenic tremor is not a diagnosis of exclusion; rather, demonstration of various clinical signs is needed to establish the diagnosis. Severity of tremor and response to treatment can be assessed using clinical rating scales as well as using electrophysiological measurements. This article provides a broad overview of tremor patient treatment.

Annals of Indian Academy of Neurology

Continuous monitoring of essential tremor using a portable system based on smartwatch

19 Nov 2016

Essential tremor (ET) shows amplitude fluctuations throughout the day, presenting challenges in both clinical and treatment monitoring. Motor sensors have shown favorable performances in quantifying tremor objectively. This study demonstrates the feasibility of continuous monitoring of ET for long period during daily activities by a portable nonrestrictive system.

Research Gate

Worse and Worse and Worse: Essential Tremor Patients’ Longitudinal Perspectives on their Condition

13 Oct 2016

Essential tremor (ET) patients regularly inquire about their prognosis. Longitudinal studies are ideally suited to provide a glimpse into the evolution of tremor. Understanding the patient vantage point is valuable as it is the starting point of personalized medicine.  In this longitudinal study, ET patients are assessed as to whether they felt that their symptoms had worsened between each follow-up evaluation and try to identify specific clinical characteristics associated with this experience.


Knowledge gaps and research recommendations for essential tremor

4 Oct 2016

Essential tremor (ET) is a common cause of significant disability, but its etiologies and pathogenesis are poorly understood. Research has been hampered by the variable definition of ET and by non-standardized research approaches. The National Institute of Neurological Disorders and Stroke (USA) invited experts in ET and related fields to discuss current knowledge, controversies, and gaps in our understanding of ET and to develop recommendations for future research. 

Parkinsonism & Related Disorders Journal

Genetics of essential tremor

14 Sep 2016

While it is recognized that genes play a major role in ET with ≥50% of the affected individuals having a positive family history, identifying underlying genes in both monogenic and complex forms of ET has been a challenging task. Recent discoveries linking LINGO1, FUS and TENM4 to essential tremor have been met with cautious optimism since reproducibility and pathogenicity have been contentious in previously implicated genes.

Parkinsonism & Related Disorders Journal

Towards Improving Touchscreen Input Speed and Accuracy on Smartphones for Tremor Affected Persons

12 Sep 2016

People who are affected by tremor often have difficulties when interacting with smartphones. The uncontrollable shaking of the hands can complicate fast and accurate interaction with touchscreen based smartphones. Although recent work has shown that motion sensors incorporated in smartphones can be leveraged for detecting tremor, little work has been done to use this data to increase interaction time and accuracy for smartphone interactions. We show how motion sensor data can be used to gain higher accuracy and decrease interaction time for persons with tremor.

ACM Digital Library

A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor

25 Aug 2016

Prospective pilot trials of focused ultrasound thalamotomy with magnetic resonance imaging (MRI) guidance in patients with essential tremor have shown reductions in hand tremor, improvements in quality of life, and minimal procedural morbidity. Here we describe the results of a prospective, sham-controlled trial of MRI-guided focused ultrasound thalamotomy for the treatment of medication-refractory essential tremor.

NEJM - The New England Journal of Medicine

Evaluation of Saccadic and Smooth Pursuit Eye Movements at an Early Stage of Essential Tremor

2 Aug 2016

The improvement of ipsilateral Essential tremor (ET)  after a cerebellar stroke as well as improvement of tremor by cerebellar stimulation, either by direct magnetic stimulation or indirectly by deep brain (ventrolateral thalamic) stimulation of cerebello-thalamic afferents are given as clues indicating the role of cerebellum in producing or suppressing ET. This study tries to investigate saccadic and pursuit eye movements in a group of newly diagnosed patients with ET who had a short history of symptoms and were not using any drugs for treatment that can interfere with the results. The authors conclude that whilst the saccadic and pursuit eye movement abnormalities were present in advanced stage patients, in their early cases, no abnormality could be detected which can be ascribed to normal cerebellar (uvular) function at least in the early stages of the disease.

Journal of Neurological Science (Turkish)

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