Research News

Exploring Essential Tremor: Results from a Large Online Survey

19 Apr 2016

To better understand diagnostic and treatment patterns as well as clinical features of patients with essential tremor (ET) through a large online survey. The survey had 2857 respondents.  The findings underscore the need for increased awareness of ET to improve the diagnostic process, to understand the treatment options for ET and to develop more effective treatments with fewer side effects.

American Academy of Neurology

Development of method for quantifying essential tremor using a small optical device

6 Apr 2016

This study aimed to develop a rapid, objective, and quantitative system for measuring the severity of finger tremor using a small portable optical device (Leap Motion) and proposes three algorithms to describe tremor amplitudes.

Science Direct

Tremor Severity Estimation Using Liftware Instrumented Eating Utensil

5 Apr 2016

This study aims to demonstrate the feasibility of accurately estimating clinical tremor severity using an eating utensil (Liftware, Google Life Sciences) capable of measuring and compensating hand tremor. Tools for assessing symptoms outside the clinic are virtually non-existent. An eating utensil capable of estimating tremor severity would allow for daily, longitudinal tremor assessment.

American Academy of Neurology

Dystonia and Tremor: The Clinical Syndromes with Isolated Tremor

5 Apr 2016

Dystonia and tremor share many commonalities. Isolated tremor is part of the phenomenological spectrum of isolated dystonia and of essential tremor. The occurrence of subtle features of dystonia may allow one to differentiate dystonic tremor from essential tremor. This study reviews isolated tremor syndromes and analyses the varied phenomenology in the light of a possible relationship with dystonia.

Tremor and Other Hyperkinetic Movements (TOHM) 

Cerebellar involvement in essential tremor with and without resting tremor: A Diffusion Tensor Imaging study

29 Mar 2016

Essential Tremor with resting tremor (rET) is a debated and poorly understood clinical phenotype. Converging evidences show that neurodegeneration of the cerebellum underlies the pathophysiology of ET, but it is not known if cerebellar changes also occurs in patients with rET. The aim of this study was to evaluate cerebellar microstructure in patients with ET with- (rET) and without resting tremor (ETwr) in comparison to healthy controls by MR Diffusion Tensor Imaging (DTI). The results demonstrate the presence of microstructural changes in the cerebellum of patients with ET.

Parkinsonism & Related Disorders Journal

Unusual tremor syndromes: know in order to recognise

16 Mar 2016

Tremor is a common neurological condition in clinical practice; yet, few syndromes are widely recognised and discussed in the literature. As a result, there is an overdiagnosis of well-known causes, such as essential tremor. Many important unusual syndromes should be considered in the differential diagnosis of patients with tremor. The objective of this review is to provide broad clinical information to aid in the recognition and treatment of various unusual tremor syndromes in the adult and paediatric populations.

Journal of Neurology, Neurosurgery, and Psychiatry

Essential Tremor: What We Can Learn from Current Pharmacotherapy

4 Mar 2016

The pathophysiology of essential tremor, especially at the cellular level, is poorly understood. Although no drug has been specifically designed to treat essential tremor, several medications improve tremor, and others worsen it. Studying the mechanism of actions of these medications can help our understanding of tremor pathophysiology and contribute to future rational drug design. The authors reviewed literature, concentrating on mechanisms of action, of various medications that mitigate tremor to summarise the mechanisms of action of medications that may affect tremor in order to improve our understanding of potential neurotransmitter/receptor pathology and provide a substrate for future rational drug development.

Tremor and Other Hyperkinetic Movements (TOHM) 

Essential tremor, the olivocerebellar system and motor timing – An fMRI study

20 Feb 2016

Essential tremor (ET) is the most common tremor disorder. It has been repeatedly shown that the olivocerebellar system is involved in ET, consisting of the inferior olive nucleus (ION), dentate nucleus (DN) and cerebellar cortex. Impairment of the central timing mechanism in ET has been suggested. The olivocerebellar system plays an important role in motor timing. This study seeks to understand the role of the olivocerebellar system in ET for unraveling the mechanism of tremor genesis.

Clinical Neurophysiology

Comparison of motor and non-motor features between essential tremor and tremor dominant Parkinson’s disease

15 Feb 2016

Differential diagnosis of tremor disorders, including essential tremor (ET) and Parkinson's disease-tremor dominant type (PD-TDT), requires further investigation. Therefore, the current study aimed to compare non-motor and tremor features in order to differentiate between ET and PD-TDT.

Journal of the Neurological Sciences

Incisionless transcranial MR-guided focused ultrasound in essential tremor: cerebellothalamic tractotomy

13 Feb 2016

In the late 1960s and early 1970s, targeting of the “posterior subthalamic area (PSA)” was explored by different functional neurosurgical groups applying the radiofrequency (RF) technique to treat patients suffering from essential tremor (ET). Recent advances in magnetic resonance (MR)-guided focused ultrasound (MRgFUS) technology offer the possibility to perform thermocoagulation of the cerebellothalamic fiber tract in the PSA without brain penetration, allowing a strong reduction of the procedure-related risks and increased accuracy. This study describes the first results of the MRgFUS cerebellothalamic tractotomy (CTT) as an effective and safe approach for patients with therapy-refractory essential tremor, combining neurological function sparing with precise targeting and the possibility to treat patients bilaterally.

Journal of Therapeutic Ultrasound

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